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Gay CM, Diao L, Ca S, Zi Y, Cardnell RJ, Swisher SG , Roth JA, Glisson B, Wang J, Heymach JV, Byers LA

418,419,420 This subtype of hepatocellular carcinoma has high-density EB-associated TIL infiltration and poorer RFS and OS characteristics, which may be related to the upregulation of CD28 co-stimulatory signals, T-cell receptors and other signaling pathways in HCC-IS, leading to CD8 + T-cell depletion and thus induced immune escape 420 in gastric cancer are silenced up to 75% EBVaGC exhibits a high frequency of DNA methylation, thus serving as a strategy for the virus to evade host immune regulation

Frizzled (Fzd or Frz) Frizzled receptors are seven transmembrane G protein-coupled receptors for the Wnt family