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However, whether circulating IGF-1 levels directly aggravate prostate cancer remains elusive

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The main function of granulosa cells, relevant to oocyte development and ovarian functions, is steroidogenesis, for which different signaling pathways, including Jak/STAT, PI3K/Akt, and pro-MAPK/ERK1/2, regulate this fundamental process, all of which have a shared modulator named IGF