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Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Location of UGTs in the body LC-MS of UGT Proteotypic Peptides Hepatic UGTs 0 10 time (min) 20 30 Antibodies are not available for many UGTs due to high homology, nor are the ones available always very specific

Sometimes this can manifest in ways that may be unexpected to those affected

Smad family proteins mediate the signaling of TGF- family members, and TGF-1 was recently described to cause upregulation of glutaminase 1 in these cells via Smad-dependent pathways and nonclassical pathways (85)