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Nat Commun 2024;15(1):7323

33 TakahashiY.OakesS

Wolfe and Cyr, 2011) collectively referred to as amyloidosis (Metkar et al., 2024) Tau proteins representing the characteristic pathology of Alzheimers disease (Chen and Yu, 2023) are normally associated with stabilization of neuronal microtubules (Jesu et al., 2004), but give rise to fibrillar tangles along with -amyloid under a hyperphosphorylated state