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Description

The earlier 12-week Phase 2a trial had shown encouraging results (2.6 kg vs 0.8 kg for placebo), but the larger, longer, better-powered trial reversed that finding

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

A short 5-Amino-1MQ half life means that a single daily dose might lead to significant peaks and troughs in plasma levels, which could impact the consistency of its biological effects