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In particular, the pronounced straindependent differences observed among MSD21, MSD24, and MSD37 when grown on the same carbon source (including IR extract) across antioxidant, antiglycation, and prebiotic assays indicate that microbial metabolism and the resulting postbiotic metabolite profiles, rather than the substrate alone, are critical determinants of bioactivity

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However, the demonstration of increased homocysteine levels and the occurrence of anaemia and neuropathy [3] in metformin users suggests that biochemical vitamin B 12 deficiency may be clinically relevant [6]

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