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They do demand a higher tolerance for discomfort, but they reward the patient with remarkable, long-lasting firmness that works deep beneath the skins surface

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Thinning of fibrous caps coupled with the expansion of necrotic core zones may lead to plaque rupture, exposing prothrombotic materials, triggering platelet activation, thrombus formation, and ultimately local blood flow interruption or distal arterial embolism (Figure 2) (Shah et al., 1995

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