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The key to successfully implementing these combination strategies lies in several aspects: determining the optimal timing of administration such as initiating intervention at early or mid-stage OA, developing local delivery carriers capable of controlled drug release and properly managing their potential side effects, and ensuring good pharmacokinetic and pharmacodynamic compatibility between the combined drugs

Cancer spheroids derived exosomes reveal more molecular features relevant to progressed cancer

The simulated geometry is presented in Fig

Therefore, relying solely on mutation data might overlook low mutation frequency, high-risk cancer genes