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These collective findings establish the gut microbiome as a key modulator of gout pathogenesis through its metabolites, which act on multiple fronts including regulating purine metabolism, influencing uric acid dynamics, and shaping inflammatory responses

In addition, the most oxidizing roGFP1-iX variant roGFP1-iL has been reported as being relatively dim compared to the parent roGFP1 (Avezov et al., 2013

Lavoz C, Rodrigues-Diez RR, Plaza A, Carpio D, Egido J, Ruiz-Ortega M, et al

Traditional healers are acknowledged by the government in certain countries, such as South Africa, and are incorporated into the public healthcare system [45]