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PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega- O -acylceramide synthesis and skin permeability barrier

This line of inquiry aligns with broader scientific efforts to understand how small molecules might influence the trajectory of cellular aging within an organism

Lipid peroxidation is a crucial metabolic event in ferroptosis, resulting in the generation of lipid peroxidation products such as 4-hydroxynonenal, which contribute to oxidative damage [19]

Mol Membr Biol 24:455463 McElrath MJ, Kaplan G, Nusrat A, Cohn ZA (1987) Cutaneous leishmaniasis