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Furthermore, there are far more possible conformations for an IDP than there are experimentally determined restraints, making the problem of building a complete ensemble mathematically underdetermined

As illustrated in Additional file 1: Figure S1C, animals from both TAT and TAT-DAT NT did not differ in time spent in each duration (two-way ANOVA with repeated measures, F 1, 10 = 0.321, p = NS), suggesting that the differences in spontaneous alternation behavior were unlikely due to confounding factors such as anxiety