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J Magn Reson 155:106118 Zhang W, Li R, Shin R, Wang Y, Padmalayam I, Zhai L, Krishna NR (2013) Identification of the binding site of an allosteric ligand using STD-NMR, docking, and CORCEMA-ST calculations

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C9SN modifies the immunosuppressive tumor microenvironment (ITM) by impeding glutamine metabolism on one hand, polarizing M2-TAMs to M1-TAMs, which in turn recruits and activates CTLs, while on the other hand, C968 in the nanoaugmentation amplifies the intracellular oxidative stress by inhibiting glutamine metabolism-mediated GSH deprivation, which results in severe cell death, and also enhances the immunogenic cell death (ICD) effect [122]

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HHcy disrupts one-carbon metabolism by altering the S-adenosylmethionine/S-adenosylhomocysteine (SAM:SAH) ratio, impairing methylation capacity

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