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That is, while CAT limits concentration peaks, the PRX-Trx axis converts H 2 O 2 into directed redox relays, preventing its leakage and possible undesirable oxidative stress [39]

In the He-CAP-induced oxidative stress model, the Pt NPs demonstrated effectiveness in reducing H 2 O 2 -induced osteoarthritis by inhibiting ROS-mediated [Ca 2+ ] i release and Fas receptor activation, thereby reducing the expression of Caspase-3 and Caspase-8

175,178 The first step of the PPP pathway depends on NADP + and is the major source of NADPH in cells

5A, B and S5A) and we noticed one of the top up-regulated genes after the knockout of SLC27A5