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Lastly, when comparing children with stage 3 konzo with their unaffected siblings, we found that in addition to GPx3, Zinc-alpha-2-glycoprotein (AZGP1) and Carboxypeptidase B2 (CPB2) were major contributors to group segregation, with CP protein also being identified as being a potential contributor (Fig

However, in the microcirculation, where RBCs are in close proximity to the vasculature and Hb becomes partially oxygenated, ROS released from neutrophils, macrophages, and endothelial cells can be taken up by RBCs

however, in HF, lactylation is viewed as a protective factor

Leite JS, Raizel R, Hypolito TM, Rosa TD, Cruzat VF, Tirapegui J