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10.1016/S0891-5849(02)01009-2

Archived from the original on December 4, 2024

More recently, an in vitro study showed that SARS-CoV-2 viroporin protein induces the NLRP3-inflammasome formation in a lung epithelial cell line (95), suggesting that SARS-CoV-2 may trigger ROS-mediated NLRP3-inflammasome activation similarly to SARS-CoV

TLR4 can activate the NLRP3 inflammasome and cause microglial pyroptosis in SCI mouse models via the Janus kinase 2/signal transducer and activator of transcription 1/dead-box helicase 3 X-linked/NLRP3 signaling pathway (Wang et al., 2022b)