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The corresponding amino acid residues (ie, the amino acid residues corresponding to position 196 in a different FX polypeptide than that shown in SEQ ID NO: 4) are identified by alignment of the unmodified FX polypeptide with the polypeptide of SEQ ID NO: 134

4-Hydroxynonenal (4-HNE) 4-Hydroxynonenal (4-HNE) is a major end product of lipid peroxidation and is considered a biomarker of oxidative stress

However, the non- or slow biodegradability of pristine MSNs and MONs can lead to long-term retention in vivo, thus inducing possible toxicity risks

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