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This influence may be at least partly related to oxidative stress, since smoking habit decreases factors related to antioxidant capacity, such as uric acid 5

Surrogate variables to correct for batch effects To account for potential batch effects , we performed surrogate variable analysis (SVA) based on the DNA methylation levels at all CpG sites located on chromosome 10 using the R/Bioconductor package sva [31]

Liposomal formulations and other improved delivery methods may work faster because they are more bioavailable