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Activated Nrf2 translocates to the nucleus, where it triggers the expression of antioxidants such as glutathione redox system components, enzymes that regulate iron metabolism, and other pertinent molecules, which can inhibit ferroptosis

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Blum MA, Hayashi Y, Xiao L, Suzuki A, Sabloff B, Maru DM, Taketa T, Welsh J, Lin SH, Lee JH, Bhutani MS, Weston B, Hofstetter WL, Swisher S , Ajani JA

Addolorato G, Leggio L, Ferrulli A, Cardone S, Vonghia L, Mirijello A, et al