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Acknowledgements This study has been funded by JSPS KAKENHI Grants (24K12533 to Sato S, 25K20119 to Tamehisa T, 24K12579 to Tamura I, and 23K27734 to Sugino N) for Scientific Research from the Ministry of Education, Science, and Culture, Japan

Methods Animals Animal experiments were performed with adherence to all national and local guidelines and regulations, the Guide for the Care and Use of Laboratory Animals 25 , and the ARRIVE guidelines, and with the approval of the Institutional Animal Care and Use Committee at The University of Texas Medical Branch (UTMB)