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Conversely, the lack of a complete genome sequence, the absence of mutant strains and the need for standardization between different sources and laboratories (39, 69), are currently curbing the enthusiasm for this model

FIGURE 2 Mechanical stress induced by increased IOP in glaucoma results in increased EGF receptor expression following astrocyte activation, as well as increased levels of TNF-, matrix metalloproteinases (MMPs), endothelins, and nitric oxide synthase 2 (NOS-2), ultimately leading to a neurodegenerative response (Liddelow et al., 2017

doi: 10.3390/dj13050197 53 MeghwanshiG

In addition to its ability to enhance oxygen delivery, ITPP acts as a tumor vascular stabilizer by activating endothelial PTEN (156)