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Due to the anatomical location of ureters and thereby higher pathogen exposure, it is comprehensible that ureters showed a more differentiated cytokine profile with higher levels of regulators of the immune response, e.g

J Investig Dermatol 137:22502253

10.1038/s41746-021-00418-3 205 SbergS.LfgrenJ.PhilipsenF

However, one of the waste products of cellular energy generation is free radicals, which are highly reactive molecules that can damage cells, membranes, lipids, proteins and DNA