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Therapies enhancing GSH could become a cornerstone to reduce severity and fatal outcomes of COVID-19 disease and increasing GSH levels may prevent and subdue the disease

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Table 1 Summary table comparing diagnostic and therapeutic approaches used in neurodegenerative disorders and their relationship to the proposed integrative neurogenomics workflow

Poldip2, a molecular chaperone for p22phox, can bind to p22phox, thereby activating NOX4, regulating VSMC phenotype and migration, and establishing a connection between ROS production and cytoskeletal remodeling (88)