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Genetic deletion of Aqp4 in mouse models reduces A efflux by approximately 55%, accelerating plaque deposition [405, 406]

None known to this date

In porcine coronary artery SMCs, GPR30 activation triggers RhoA/ROCK inactivation by stimulating Epac/Rap1 and protein kinase A (PKA), leading to coronary artery relaxation [85]

Thrombin when activated through the tissue factor-mediated extrinsic pathway and subsequent prothrombinase activity 50 , amplifies local coagulation through positive feedback in the coagulation cascade 51