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Protein Cell 12(9):675679 Liu J, Kang R, Tang D (2022) Signaling pathways and defense mechanisms of ferroptosis

Glutamate is one of the most important amino acids in the body and plays a crucial role in the nervous system (Onaolapo and Onaolapo, 2021)

A 'substrate-limitation' model in FM is supported by elevated homocysteine levels observed in FM/chronic fatigue syndrome cohorts, by associations between symptoms and the MTHFR C677T (rs1801133) variant, and by gene-environment interactions showing that rs1801133 modifies the effect of physical activity on fatigue