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These results suggested that keloid fibroblasts underwent pro-senescence regulation earlier compared with normal skin fibroblasts via p53-pS15 under serum limitation stimulus, and p53-pS15 and FOXO4 translocated from the nucleus to the cytoplasm during FOXO4-DRI treatment

Thus, the regulation of glutamine metabolism by mTORC1 is cell type-dependent and needs to be elucidated further

Br J Pharmacol 178:33273341 Aleksandrov DA, Zagryagskaya AN, Pushkareva MA, Bachschmid M, Peters-Golden M, Werz O, Sudina GF (2006) Inhibition of 5-lipoxygenase activation in polymorphonuclear leukocytes and MonoMac6 cells by cholesterol and its anionic derivatives