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Ogidi et al

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Introduction Non-alcoholic fatty liver disease (NAFLD) is currently the most predominant chronic liver disease worldwide and is a clinicopathological syndrome ( Gentiopicroside (GPS), a type of iridoid glycosides component extracted from the Chinese herbal medicine Gentiana manshurica Kitag., Gentiana scabra Bunge., Gentiana triflora pall or Gentiana rigescens Franch., is also the main active ingredient of this herbal medicine and has anti-inflammatory, hypolipidemic, and antioxidant effects ( Recent studies have found a close association between metabolites and intestinal flora and NAFLD pathogenesis ( Therefore, in this study, we performed untargeted metabolomics and 16S gut microbiome sequencing studies on high-fat diet (HFD) -induced mice sera

doi: 10.3389/fphar.2025.1551843 Received 26 December 2024 Accepted 09 June 2025 Published 02 July 2025 Volume 16 - 2025 Edited by Ting Shen, Yangzhou University, China Reviewed by Shuo Yuan, University of Virginia, United States Yan Hu, Second Affiliated Hospital of Dalian Medical University, China Updates Copyright 2025 Mao, Huang, Li, Sun, Zhang, Cheng, Zeng, Lei, Wang and Yao