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The abdomen, thigh, and upper arm are all acceptable sites for both CagriSema and tirzepatide

p K values for DHIQ, S -THIQ, and R -THIQ were sourced from the chemical databases LookChem and ChemicalBook, which agreed with experimentally determined pK values in PubChem for isoquinoline and 1,2,3,4-tetrahydroisoquinoline, contained within the DHIQ and THIQ compounds

Payload conjugation was achieved through reduced interchain cysteines using either conventional maleimide chemistry or a more plasma-stable arylpropiolonitrile (APN) handle, resulting in well-defined ADCs with moderate drug loading