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However, in M.tb -infected immunocompromised mice, JHU083 showed reduced therapeutic efficacy [36]

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In the previous study, we had successfully generated FGF5 -knockout heterozygous sheep using the CRISPR/Cas9 system by direct one-step cytoplasmic injection of Cas9 mRNA and sgRNA into zygotes, and the relationship between FGF5 gene and wool length in sheep was proved 22