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We solved cryo-EM structures of OCTN2 (~62.7 kDa) in a substrate-free inward-facing conformation to 3.0 resolution, a carnitine-bound occluded conformation to 2.7 resolution (Fig

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Muchos pacientes con anomalas metablicas, como enfermedades cardacas, hiperlipidemia, enfermedad renal, cirrosis heptica, desnutricin, disfuncin tiroidea y ciertas enfermedades musculares y neurolgicas, suelen presentar niveles bajos de carnitina