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In clinical trials, intranasal administration of ketorolac most commonly resulted in local adverse events including nasal irritation or discomfort (15%), rhinalgia (13%), increased lacrimation (5%), rhinitis (2%), and throat irritation (4%) (5)

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What we do not know Several questions remain unanswered: Does prolonged amylin receptor agonism produce any adaptive changes in receptor expression or sensitivity that could alter efficacy or safety over years