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The key novelty of our study is that higher PC levels are associated with reduced fibrin clot permeability in both hyper- and hypothyroid group, while plasma clot lysability, unrelated to PAI-1 or TAFI concentrations or activity, showed association with PC solely in the former group, suggesting the structural alterations to fibrin provoked by hyperthyroidism affect susceptibility to lytic degradation to a larger extent

M.Al-BrakatiA.et al (2021)

Low-dose naltrexone (LDN): A promising treatment in immune-related diseases and cancer therapy

It modulates brain circuits involved in libido rather than directly altering gonadotropins