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Gln depletion treatment activates FADD and caspase-8-dependent apoptosis involving pro-apoptotic TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) in tumour cells, while metabolic stress induced by glutamine deprivation leads to the downregulation of the GCN2-non-dependent FLICE-inhibitory protein (FLIP), which promotes caspase-8 activation and apoptosis [55]

For both cell types we observed similar expression of GPX3 on transcript level, comparable to expression of ATP-dependent RNA helicase DHX8 (DHX8) used as endogenous control 45 (Fig

2A and 2Bshow the number of the day post-exposure

Results: We analyzed data from 87,678 participants (mean age 47.4 17.1 years, 52% women)