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doi: 10.1007/s10517-018-4227-2

Large quantities of intracellular ROS hyperproduction are believed to participate in a diverse scope of either nonmalignant or malignant diseases that affect the nervous, cardiovascular, and respiratory tract disorders, including chronic obstructive pulmonary disease, GIT (e.g., inflammatory bowel disease and irritable bowel syndrome), urogenital, reproductive, and metabolic systems [20, 24], besides mental and immune system disorders [25]

The programme is funded by NWO, the national research council of the Netherlands (Project No

Accentuation of Signal Amplification this may occur with an increase in receptor phosphorylation or increased enzymatic activity