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In the case of iron metabolic disorder, the low expression of FTH1 and the overexpression of TFR1 often lead to the excessive accumulation of Fe 2+ ions, which induce the production and accumulation of a large amount of ROS through Fenton reaction and eventually promote cell ferroptosis ( Lipid Peroxidation Lipid peroxidation plays a driving role in the occurrence of ferroptosis, which can be completed by non-enzymatic or enzymatic reaction

What is truly promising is that there appears to be little to no toxicity in non-neoplastic cells

Management of very early fetal anemia resulting from red-cell alloimmunization before 20 weeks of gestation