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Their hemodynamic parameters are uniformly worse, encompassing higher filling pressures, lower cardiac output, and elevated pulmonary vascular resistance

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Noteworthy, deletion of GluN1 also causes reduced expression of the transcriptional coactivator PGC1-alpha, which is highly expressed in PV interneurons and is a positive regulator of the expression of genes implicated in mitochondrial function and antioxidant defence [131]