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5), and by inference, neurotoxic damage.53 Forgione and colleagues had previously hypothesized that GPX1 deficiency directly induces an increase in vascular oxidative stress, with attendant endothelial dysfunction.54 Glutathione peroxidases, particularly GPx1 have also been implicated in the development and prevention of many common and complex diseases, including cancer and cardiovascular disease (Fig

doi: 10.1016/j.ajcnut.2023.08.020, 9

Transparency about the regulatory status of the treatment : A responsible doctor will clearly explain whether a proposed treatment is HSA-approved for its intended use, or whether it constitutes off-label use, and will document informed consent accordingly