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However, preclinical studies demonstrate therapeutic effects with once-daily or even less frequent administration, suggesting tissue distribution, receptor binding, or cellular signaling effects extend beyond plasma clearance

Peer review Peer review information Nature Communications thanks Toni Giorgino and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

At the same time, this supports the likely role of BPC 157, as a novel mediator of cytoprotection (1-7), in providing a beneficial effect in help rescuing failed sphincter function