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Sedelnikova, O

1 Introduction Renal cell carcinoma (RCC) is a malignant tumor originating from the renal tubular epithelial cells, accounting for 90-95% of all kidney cancers ( The PI3K-AKT-mTOR signaling pathway functions as a central regulatory pathway governing cell survival, proliferation, metabolism, and angiogenesis ( Accordingly, from a systems biology perspective, this review integrates the genetic basis of RCC with the aberrant activation mechanisms of the PI3K-AKT-mTOR pathway, systematically dissects its network functions in metabolic reprogramming, angiogenesis, and the regulation of apoptosis and autophagy, and establishes its central hub role in RCC initiation and progression

This was done to detect phosphorylated p38 (p-p38, yellow)

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