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Substance-Related and Addictive Disorders associated with an irresistible desire for the substance and drug tolerance Tolerance Pharmacokinetics and Pharmacodynamics that leads to increases in dosage Dosage Dosage Calculation and withdrawal symptoms during abstinence

During treatment with Vitamin U (100 mg/kg, b.wt, oral) alone, Vitamin-U (150 mg/kg, b.wt, oral) alone, Vitamin-U alone (150 mg/kg, b.wt, oral), Vitamin-U (100 mg/kg, b.wt, oral) combined with Vitamin-E (200 mg/kg, b.wt, oral) and Vitamin-E (200 mg/kg, b.wt, oral) alonelevel significantly decreased LPO level

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