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The nuclear factor erythrocyte-related factor 2 (Nrf2) is the critical transcription factors of the antioxidant response, prevents lipid peroxidation and ferroptosis by increasing the transcription of a series of antioxidant-responsive genes [59], such as NAD(P)H, quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), glutathioneS-transferaseA1(GSTA1), glutamate-cysteineligase(GCS) [60]

Consequently, there is a necessity to design compounds capable of irreversibly targeting and blocking ASCT2 transporter proteins

2019) and exhibit SOD-, catalase-, and oxidase-like activities (Ren et al