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In recent years, various novel technologies or approaches have been incorporated to fabricate the new generation of NGCs composed of various types of biomimetic and functional scaffolds with modifications in their basic topological, biochemical, and physical properties, which not only provides physical neural support but can also rebalance the disturbed neuronal microenvironment through modulating the four key neural regeneration factors, including immune responses, intraneural vascularization, bioenergetic metabolism, and bioelectrical conduction [62, 63]

Calcium channel Calcium is a critical regulator of cardiac function by maintaining cardiac excitation-contraction coupling, and disturbances in cardiac calcium regulation are a major contributor to left ventricular dysfunction in iron overload cardiomyopathy ( 2+ channels participate in iron uptake into cardiomyocytes (61)

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Inhibition of calpain alleviates coxsackievirus B3-induced myocarditis through suppressing the canonical NLRP3 inflammasome/caspase-1-mediated and noncanonical caspase-11-mediated pyroptosis pathways