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Increased DNMT3B levels accelerate the DNA methylation of the Pink1 (PTEN induced kinase 1) promoter, inhibiting PINK1 expression and promoting ferroptosis and brain damage[129]

Endoplasmic reticulum oxidoreductin-1alpha (Ero1alpha) improves folding and secretion of mutant proinsulin and limits mutant proinsulin-induced endoplasmic reticulum stress

Handb Clin Neurol 127:4566

In clinical trials of adult and pediatric patients with HoFH, patients were provided daily dietary supplements of vitamin E, linoleic acid, ALA, EPA, and DHA