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The clearance (L/hr) of APAP increased from 2.02 L/hr at 1 month of age to 4.09 L/hr at 1 year of age to 14.27 L/hr at 16 years of age (based on our own analyses on the published mean values with a Spearman correlation, there is a significant correlation between age and APAP clearance, p G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A Exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failure

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Future research should focus on developing more accurate PRS models and verifying their applicability in different populations

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Molecular modeling suggested that AEDG may bind to histone H1 regions that interact with DNA, providing a proposed epigenetic mechanism for changes in neurogenesis-related gene expression and protein synthesis

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however, the nomenclature for the liver lobes varies among authors

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