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This inhibition preserves cellular NAD+ levels by reducing their consumption, simultaneously increasing GLUT4 transporter expression and activating sirtuin 1, known as the "longevity gene." The compound exhibits high membrane permeability and selectivity without affecting related methyltransferases or NAD+ salvage pathway enzymes, creating targeted metabolic effects while maintaining cellular safety

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Skovgrd K, Barrientos SA, Petersson P et al (2023) Distinctive effects of D1 and D2 receptor agonists on cortico-basal ganglia oscillations in a rodent model of L-DOPA-Induced dyskinesia

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