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However, in an April 2013 study of 50 dogs (including 20 CKCSs), the researchers reported that: "Cardiac fibrosis and arteriosclerosis in dogs with MMVD are reflected by circulating cTnI [cardiac Troponin-I] concentration, but not by aldosterone concentration or renin activity

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Unfortunately, they also kill beneficial gut bacteria, creating a void in the gut microbiota