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Selenium deficiency and fulvic acid supplementation induces fibrosis of cartilage and disturbs subchondral ossification in knee joints of mice: an animal model study of Kashin-Beck disease

Conversely, mitigating oxidative stress specifically in HCs (via Gpx4 overexpression) reduced ERK phosphorylation in SCs, likely through EGFR signaling across the SC membrane, leading to GSDMD activation

DOX: 4 mg/kg