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Understanding keloid pathobiology from a quasi-neoplastic perspective: less of a scar and more of a chronic inflammatory disease with cancer-like tendencies

They found that metformin can not only significantly improve 17-hydroxylase expression in ovarian structures, reduce body weight, increase glucose and insulin levels in PCOS rats, but also promote the proliferation of sphincteric interstitial and mesenchymal cells and improve angiogenesis, which consequently promotes follicular development and ovulation (Mahamed et al., 2018)

In the 5 years before enrollment, he had a 15% BMI reduction (decrease from 34 kg/m 2 ) secondary to a glucagon-like peptide-1 (GLP1) receptor agonist (liraglutide 20152021 and dulaglutide 2021 onwards) for diabetes management but a rising M-spike that increased 4-fold (0.24 to 1.21g/dL) during that period

In absolute vitamin B12 deficiency in serum, MMA starts to increase as vitamin B12 drops below 250 pmol/L