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Mechanism data: CJC1295 raises GH/IGF1 in humans CJC1295 trial

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proBDNF/BDNF axis exerts different physiological effects, for example, proBDNF/p75 NTR with sortilin receptor form a proBDNF/p75 NTR sortilin complex, resulting in various signaling pathways being activated, which causes neuronal apoptosis and regulation of neuronal survival and differentiation (Al-Yozbaki et al., 2020)