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16 These impaired DNA modifications can accelerate aging and cause neurodegenerative, carcinogenesis, autoimmune, cardiovascular, and other diseases

Although speculative, it could be hypothesised that this proposed increase in susceptibility of OPCs to ROS-induced damage compared to other brain cell types could, at least in part, be driven by ROS induced alterations in DNA methylation in these cells [6, 30, 32]