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This group only suggests such treatment when IGF-1 deficiency prevails, acting merely as a substitutive therapy, and never to exploit its multiple actions

Stopping the mechanical folding of the skin is step one

On the other hand, ginkgo and some flavonoids may inhibit CYP3A4 or Pg-pg, leading to increased drug exposure and an increased risk of toxicity, such as myelosuppression, neuropathy, or hepatotoxicity (203)